HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline-3-carboxylic acid → 2,3-Diaminobenzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| Reactant | Methyl 2-amino-3-nitrobenzoate | HCID 607264 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Product | 2,3-Diaminobenzoic acid methyl ester | HCID 571825 | — |
| Product | 2-Amino-3-[(isoquinoline-3-carbonyl)-amino]-benzoic acid methyl ester | HCID 66940314 | — |
Reaction Steps
The 2,3-diamino-benzoic acid methyl ester was synthesized from 2-amino-3-nitro-benzoic acid methyl ester (2.0 g, 10.2 mmol) as described in general procedure C. 1.7 g (10.2 mmol) of the above synthesized diamine was reacted with 1.7 g (10.0 mmol) of isoquinoline-3-carboxylic acid and 4.6 g (12.0 mmol) of HBTU as described in general procedure A to provide 2-amino-3-[(isoquinoline-3-carbonyl)-amino]-benzoic acid methyl ester. LCMS: 322 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c8f283f1b66446b38efbc59bf7da5dfe |
| Source note | uspto-grants-2015_02 |