HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1844999Generated: November 4, 2026
Diisopropylethylamine → HCID 178504988, compound
https://huagongshe.com/reaction/1844999
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 66940243 | HCID 66940243 | — |
| Reactant | HCID 178508178 | HCID 178508178 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178504988 | HCID 178504988 | 10.2% |
Reaction Steps
To a solution of 30 mg (0.11 mmol) of 7-methanesulfonylamino-isoquinoline-3-carboxylic acid in DMF (0.8 mL) was added 60 mg (0.15 mmol) of HBTU and DIEA (0.1 mL). The mixture was stirred for 10 min and then 24 mg (0.1 mmol) of 2-amino-3H-benzoimidazole-4-carboxylic acid (1H-imidazol-2-yl)-amide (intermediate B) was added. The reaction was heated at 80° C. for 1 h. After usual work up, the residue was purified by column chromatography eluting with DCM/methanol (v/v=10:1 to 8:1) to afford 5 mg (9%) of 7-methanesulfonylamino-isoquinoline-3-carboxylic acid [7-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-amide. LCMS: 491 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946259B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-df6c06430bc145d8840418071744077c |
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| Source note | uspto-grants-2015_02 |
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