HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 1-(2-Methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-(2-Methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid methyl ester | HCID 66940422 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2-Methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid | HCID 66940461 | 91.7% |
Reaction Steps
1-(2-methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid was prepared according to General Procedure B using 49 mg (0.187 mmol) of 1-(2-methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid methyl ester, 0.28 mL of 2 N aq. LiOH, 2 mL of THF and 0.5 mL of methanol stirring at room temperature for 1 h. 42.4 mg (91%) of 1-(2-methylsulfanyl-ethyl)-isoquinoline-3-carboxylic acid was obtained. LCMS: 248 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8f757288d07142bc86af2fcc9990292a |
| Source note | uspto-grants-2015_02 |