HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[7-[(1H-Imidazol-2-ylamino)carbonyl]-1H-benzimidazol-2-yl]thieno[2,3-c]pyridine-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | thieno[2,3-c]pyridine-5-carboxylic acid(WXC09021) | HCID 12277675 | — |
| Reactant | HCID 178508178 | HCID 178508178 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[7-[(1H-Imidazol-2-ylamino)carbonyl]-1H-benzimidazol-2-yl]thieno[2,3-c]pyridine-5-carboxamide | HCID 58724481 | 3% |
Reaction Steps
2.6 mg (3%) of thieno[2,3-c]pyridine-5-carboxylic acid [4-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-amide was prepared according to general procedure A using 54 mg (0.3 mmol) thieno[2,3-c]pyridine-5-carboxylic acid, 61 mg (0.25 mmol) intermediate B (2-amino-3H-benzoimidazole-4-carboxylic acid (1H-imidazol-2-yl)-amide), 114 mg (0.3 mmol) of HBTU, 0.106 mL (0.6 mmol) of DIEA in 1 mL of DMF stirring at 85° C. for 1 h. LCMS: 404 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-237b0006b4fd4523950d5716579d2cad |
| Source note | uspto-grants-2015_02 |