HCID 66940385, compound → HCID 178498145, compound

HRID 1845052Notes

Reaction equation

HRID 1845052 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:13]2[NH:12][C:11]([NH2:14])=[N:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].COC(=O)C1C=C([C:24]#[N:25])C=C([N+]([O-])=O)C=1N>>[CH3:1][O:2][C:3]([C:5]1[C:13]2[NH:12][C:11]([NH2:14])=[N:10][C:9]=2[CH:8]=[C:7]([C:24]#[N:25])[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 66940385HCID 66940385, compoundHCID 178497585HCID 178497585, compound

Product 1

HCID 178498145HCID 178498145, compoundYield 50%

Procedure

0.28 g (50% overall yield) of 2-Amino-6-cyano-3H-benzoimidazole-4-carboxylic acid methyl ester was synthesized according to procedures described for the synthesis of 2-Amino-3H-benzoimidazole-4-carboxylic acid methyl ester starting from 1.0 g of 2-amino-5-cyano-3-nitro-benzoic acid methyl ester. LCMS: 269 (M+1)+.

Sources & evidence

ORD record
ord-bbee43976819456a80bec90e51863cd3
Source dataset
uspto-grants-2015_02
Patent number
US08946259B2

Reaction notes

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