HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → 2-Amino-6-methoxy-1H-benzimidazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | HCID 11030440 | HCID 11030440 | — |
| Reactant | methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate | HCID 24730367 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-6-methoxy-1H-benzimidazole-7-carboxylic acid | HCID 66940400 | — |
Reaction Steps
0.8 g (4.4 mmol) of 2,3-diamino-6-methoxy-benzoic acid was subjected to a similar cyclization condition as illustrated in intermediate A by using 0.7 g (6.6 mmol) of BrCN in methanol to produce 2-amino-5-methoxy-1H-benzoimidazole-4-carboxylic acid. LCMS: 208 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-b2adacb1212044b68c3db01805235dfc |
| Source note | uspto-grants-2015_02 |