HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid methyl ester | HCID 66940311 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid | HCID 66940490 | — |
Reaction Steps
2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid was synthesized according to General Procedure B using 417 mg (1.2 mmol) 2-[(isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid methyl ester, 2.4 mL of 2 N aq. LiOH, 12 mL of THF and 3 mL of methanol at 40° C. for 4 h. 141 mg (0.423 mmol, 35%) of the product was obtained. LCMS: 334 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-a7ef4fc138bc40cdb4a5afab6a895f96 |
| Source note | uspto-grants-2015_02 |