Ethanol → 4-Phenyl-4-(4-trifluoromethylphenoxy)piperidine

HRID 184510Notes

Reaction equation

HRID 184510 reaction equation
[CH3:35][CH2:36][OH:37].[K+:34].[O:1]([C:2](=[O:3])[N:10]1[CH2:11][CH2:12][C:13]([O:16][c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[CH2:14][CH2:15]1)[c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1.[OH-:33]>>[NH:10]1[CH2:11][CH2:12][C:13]([O:16][c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[CH2:14][CH2:15]1

Participants

5

Reactant 4

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 21428717HCID 21428717, compound

Product 1

HCID 212682524-Phenyl-4-(4-trifluoromethylphenoxy)piperidine

Sources & evidence

ORD record
ord-416c8a07396f40f4bfc4d0c1480d5073
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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