HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → 2-amino-6-ethylsulfanyl-1H-benzoimidazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate | HCID 24730367 | — |
| Reactant | 2,3-Diamino-5-ethylsulfanyl-benzoic acid ethyl ester | HCID 66940505 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-amino-6-ethylsulfanyl-1H-benzoimidazole-4-carboxylic acid ethyl ester | HCID 66940818 | 90% |
Reaction Steps
0.9 g (3.75 mmol) of 2,3-diamino-5-ethylsulfanyl-benzoic acid ethyl ester was subjected to a similar cyclization condition as illustrated in intermediate A by using 1.2 g (11.3 mmol) of BrCN in methanol to produce 0.9 g (3.4 mmol, 90%) of 2-amino-6-ethylsulfanyl-1H-benzoimidazole-4-carboxylic acid ethyl ester. LCMS: 266 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-80ce4862efab40709df5717a8e7e4f1c |
| Source note | uspto-grants-2015_02 |