HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178469417, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-amino-6-ethylsulfonyl-1H-benzoimidazole-4-carboxylic acid ethyl ester | HCID 66940531 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178469417 | HCID 178469417 | — |
Reaction Steps
0.30 g (1.5 mmol) of isoquinoline-3-carboxylic acid and 800 mg (2.1 mmol) HBTU were dissolved in 3.0 mL of DMF and 0.6 mL of DIEA and treated with 0.28 g (0.94 mmol) of 2-amino-6-ethylsulfonyl-1H-benzoimidazole-4-carboxylic acid ethyl ester as described in general procedure A to produce 6-ethylsulfonyl-2-[(isoquinoline-3-carbonyl)-amino]-3H-benzoimidazole-4-carboxylic acid ethyl ester. LCMS: 453 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946259B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-6088231b5c4c4e838e2aab3058b4e8e0 |
| Source note | uspto-grants-2015_02 |