反应详情

温度

60 °C

To a stirred solution of (R)-5-(oxiran-2-yl)-2-(trifluoromethyl)pyridine (2.72 g, 14.4 mmol) in acetonitrile (200 mL) were added lithium perchlorate (20 g, 0.19 mol) and sodium azide (3.7 g, 57 mmol). The mixture was stirred at 60° C. overnight and TLC indicated completion of the reaction. After cooling, the mixture was filtered through Celite and the filtrate was concentrated. The residue was treated with water and extracted with EtOAc. The combined organic layers were dried, and concentrated. The residue was purified by silica gel column to afford the title compound.

1. customcompletion of the reaction
2. temperatureAfter cooling
3. filtrationthe mixture was filtered through Celite
4. concentrationthe filtrate was concentrated
5. additionThe residue was treated with water
6. extractionextracted with EtOAc
7. customThe combined organic layers were dried
8. concentrationconcentrated
9. customThe residue was purified by silica gel column