참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl Thioglycolate | HCID 16907 | — |
| 반응물 | 3-Fluoro-4-formylbenzonitrile | HCID 2783150 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 6-cyanobenzo[b]thiophene-2-carboxylate | HCID 11031280 | — |
반응 단계
A round bottom flask was charged with 3-fluoro-4-formylbenzonitrile (9.00 g, 60.4 mmol), dimethyl sulfoxide (90 mL), triethylamine (18.0 mL, 129 mmol), and subsequently methyl 2-mercaptoacetate (5.40 mL, 60.4 mmol). The reaction mixture was heated at 80° C. for 2 hours. After cooling, the reaction mixture was poured into water and the precipitated product was collected by filtration, dried and used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08946439B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_02 |
|---|
| ORD ID | ord-f035714f2b384703a09adaafccd42b7d |
|---|
| 출처 메모 | uspto-grants-2015_02 |
|---|
