Hydrochloric Acid → HCID 58188124, compound

Participants

Reaction Steps

A mixture of (S)-methyl5-(1-hydroxypropan-2-ylcarbamoyl)-4′-methylbiphenyl-3-carboxylate (105 mg, 0.321 mmol), lithium hydroxide (9.98 mg, 0.417 mmol), THF (3 mL), and water (1 mL) was stirred at room temperature for 12 h. LC-MS indicated completion of the reaction. The reaction mixture was diluted with water (5 mL) and acidified with 1N aq. HCl to pH=3 and extracted with EtOAc (50 mL×3). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated to yield a white solid. LC-MS: 314.4 [M+1]+.

Provenance & Evidence