Isobutylamine → HCID 58187986, compound

Participants

Reaction Steps

To a mixture of (S)-5-(1-hydroxypropan-2-ylcarbamoyl)-4′-methylbiphenyl-3-carboxylic acid (25 mg, 0.080 mmol), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (30 mg, 0.16 mmol), 1-hydroxybenzotriazole hydrate (12 mg, 0.080 mmol), CH2Cl2 (3 mL), and DMF (0.5 mL) were added 2-methyl-1-propanamine (12 mg, 0.16 mmol) and N,N-diisopropylethylamine (0.021 mL, 0.12 mmol). The mixture was stirred at room temperature overnight, and then diluted with EtOAc, washed with aq. NaHCO3, brine, dried (Na2SO4), and concentrated. The residue was purified by preparative HPLC (100×21.2 mm C18 column, 30-70% MeCN/water[10 mM Et2NH]) to afford a white foam.

Provenance & Evidence