反应详情

温度

50 °C

A mixture of methyl 4′-methyl-5-(methylsulfonyl)biphenyl-3-carboxylate (0.55 g, 1.8 mmol), MeOH (50 mL) and 2N aq. NaOH (4 mL) was stirred at 50° C. for 3 h. After cooling the mixture was concentrated in vacuo and acidified with 1N aq. HCl to pH<4 and extracted with EtOAc (100 mL). The organic layer was washed with brine, dried (Na2SO4), and concentrated to yield a white solid. LC-MS: 289.3 [M−1]−; 1H NMR (400 MHz, CDCl3): δ 8.61 (t, 1H, J=1.6 Hz), 8.59 (t, 1H, J=1.6 Hz), 8.39 (t, 1H, J=1.6 Hz), 7.58 (d, 2H, J=8.0 Hz), 7.33 (d, 2H, J=8.0 Hz), 3.15 (s, 3H), 2.44 (s, 3H).

1. temperatureAfter cooling the mixture
2. concentrationwas concentrated in vacuo
3. extractionextracted with EtOAc (100 mL)
4. washThe organic layer was washed with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customto yield a white solid