反应详情

A mixture of methyl 3-bromo-5-(pyrrolidine-1-carbonyl)benzoate (1.2 g, 3.8 mmol), 5-methyl-2-(tributylstannyl)pyridine (0.90 mL, 2.6 mmol), tetrakis(triphenylphosphine)palladium(0) (100 mg, 0.086 mmol) under argon was subjected to microwave irradiation at 120° C. for 2 hour. The mixture was cooled to room temperature and the precipitate was collected by filtration and rinsed with hexane to afford the title compound as a white solid. The filtrate was concentrated and purified via flash chromatography to afford another crop of the desired product. LC-MS: 325.1 [M+1]+.

1. customirradiation at 120° C. for 2 hour
2. filtrationthe precipitate was collected by filtration
3. washrinsed with hexane