HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1845227Generated: October 31, 2026
Diisopropylethylamine → 5-(3-Hydroxyazetidine-1-carbonyl)-4'-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)biphenyl-3-carboxamide
https://huagongshe.com/reaction/1845227
Participants
| Role | Name | HCID | Charge |
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| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-(Aminomethyl)-2-(trifluoromethyl)pyridine | HCID 2737718 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 5-(3-Hydroxyazetidine-1-carbonyl)-4'-methylbiphenyl-3-carboxylic acid | HCID 58188357 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(3-Hydroxyazetidine-1-carbonyl)-4'-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)biphenyl-3-carboxamide | HCID 44222976 | — |
Reaction Steps
To a solution of 5-(3-hydroxyazetidine-1-carbonyl)-4′-methylbiphenyl-3-carboxylic acid (80 mg, 0.26 mmol) in N,N-dimethylformamide (1.5 mL) were added C-(6-trifluoromethyl-pyridin-3-yl)-methylamine (70 mg, 0.40 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (200 mg, 0.53 mmol), and N,N-diisopropylethylamine (200 pt, 1.15 mmol). The reaction mixture was stirred for 16 hours at 25° C. The reaction mixture was purified by preparative HPLC to afford a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946439B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-67e6e2a1c3db41bc9a2700cb2e671b51 |
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| Source note | uspto-grants-2015_02 |
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