Diisopropylethylamine → N3,4'-Dimethyl-N5-((6-methylpyridin-3-yl)methyl)-N3-(pyridin-4-yl)biphenyl-3,5-dicarboxamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	4-(Methylamino)pyridine	HCID 123098	—
Edukt	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Edukt	4'-Methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylic acid	HCID 58188051	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	N3,4'-Dimethyl-N5-((6-methylpyridin-3-yl)methyl)-N3-(pyridin-4-yl)biphenyl-3,5-dicarboxamide	HCID 58188202	—

Reaktionsbedingungen

Temperatur	25 °C

Reaktionsschritte

To a solution of 4′-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)-biphenyl-3-carboxylic acid (50 mg, 0.134 mmol) in N,N-dimethylformamide (1 mL) were added N-methylpyridin-4-amine (40 mg, 0.37 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (120 mg, 0.32 mmol) and N,N-diisopropylethylamine (120 μL, 0.69 mmol). The reaction mixture was stirred for 16 hours at 25° C. The reaction mixture was purified by preparative HPLC to afford the final product as a light color solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08946439B2
Quelldatensatz	uspto-grants-2015_02
ORD ID	ord-648ab5c304614b94af63e29779fb5a6f
Quellennotiz	uspto-grants-2015_02