Methanol → HCID 58188052, compound

Participants

Reaction Steps

A mixture of ethyl 4′-bromo-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylate (3.3 g, 8.2 mmol), MeOH (100 mL), water (20 mL), and lithium hydroxide (0.90 g, 38 mmol) was stirred at room temperature for 3 h. The mixture was concentrated in vacuo and the residue was acidified with 1N aq. HCl to pH 2-3 and extracted with EtOAc (2×100 mL). The combined organic layers were dried (Na2SO4) and concentrated to afford a white foam. LC-MS: 376.1 [M+1]+.

Provenance & Evidence