Acetyl chloride → HCID 58188103, Verbindung

HRID 1845244Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1845244
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:11][CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[CH:10]=1)[C:5]([OH:7])=[O:6].[C:17](Cl)(=O)C>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([S:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16]2)[CH:10]=1)[C:5]([O:7][CH3:17])=[O:6]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 58188286HCID 58188286, Verbindung

Produkt 1

HCID 58188103HCID 58188103, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 3-bromo-5-(cyclopentylthio)benzoic acid (1.49 g, 4.95 mmol) in methanol (40 mL) was treated with acetyl chloride (3.87 mL, 54.4 mmol) at 0° C. The reaction mixture was heated to reflux overnight, and then concentrated under reduced pressure. The residue was purified by flash chromatography (0-20% EtOAc/hexane) to afford the title compound as a colorless oil.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux overnight
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by flash chromatography (0-20% EtOAc/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-6041f20e2bb7498fadc36ca541e96e32
Quelldatensatz
uspto-grants-2015_02
Patentnummer
US08946439B2

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