Hydrochloric Acid → HCID 58188384, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-(cyclopentylsulfonyl)-4′-methylbiphenyl-3-carboxylate (0.34 g, 0.95 mmol) in tetrahydrofuran (15 mL) was added 2.5 M aqueous lithium hydroxide solution (1.0 mL, 2.5 mmol). The reaction mixture was stirred at 60° C. overnight. The aqueous solution was acidified with 15% HCl (aq.) to pH=5, and extracted with EtOAc. The combined organic layers were concentrated in vacuo to afford the title compound as a white solid.

Provenance & Evidence