Diisopropylethylamine → HCID 58188002, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	(R)-1-(2-Methyl-5-pyrimidinyl)ethanamine	HCID 55281681	—
Reactant	HCID 58188384	HCID 58188384	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 58188002	HCID 58188002	—

Reaction Conditions

Temperature	25 °C

Reaction Steps

To a solution of 5-(cyclopentylsulfonyl)-4′-methylbiphenyl-3-carboxylic acid (50 mg, 0.14 mmol) in N,N-dimethylformamide (1 mL) were added (R)-1-(2-methylpyrimidin-5-yl)ethanamine (40 mg, 0.29 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (120 mg, 0.32 mmol) and N,N-diisopropylethylamine (140 μL, 0.80 mmol). The reaction mixture was stirred for 16 hours at 25° C. The reaction mixture was purified by preparative HPLC to afford the final product as a light color solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08946439B2
Source dataset	uspto-grants-2015_02
ORD ID	ord-4b66aced905e47c3bcdb4c44b97fa43d
Source note	uspto-grants-2015_02