HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Methyl 3-bromo-5-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 3-Bromo-5-hydroxybenzoic acid | HCID 15735511 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-bromo-5-hydroxybenzoate | HCID 53216607 | — |
Reaction Steps
To a solution of 3-bromo-5-hydroxybenzoic acid (3.41 g, 15 mmol) (J. Chem. Soc. 1955, 463) in anhydrous methanol (80 mL) was added acetyl chloride (2.56 mL, 36 mmol) at 0° C. The mixture was then heated under reflux overnight. The volatiles were removed in vacuo to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946439B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-fd0f1a158cc048039864667c2bae6daf |
| Source note | uspto-grants-2015_02 |