Ammonium Chloride → HCID 58188278, compound

Participants

Reaction Steps

To a stirred solution of dimethyl 5-(5-methylpyridin-2-yl)isophthalate (1.78 g, 5.93 mmol) in methanol (100 mL) was added sodium tetrahydroborate (2.0 g, 0.053 mol) at 0° C. After 3 h, the reaction was treated with sat. aq. NH4Cl and the volatiles were removed in vacuo. The residue was dissloved in water, basified to pH=9 by addition of NaHCO3, and then extracted with CH2Cl2 (70 mL×3). The combined organic layers were dried over anhydrous MgSO4 and concentrated. The residue was purified by flash chromatography to afford the title compound.

Provenance & Evidence