Sulfuric Acid → HCID 58188147, compound

Participants

Reaction Steps

To a stirred solution of methyl 3-(methoxymethyl)-5-(5-methylpyridin-2-yl)benzoate (75 mg, 0.28 mmol) in 1,4-dioxane (3 mL) and water (0.3 mL) was added lithium hydroxide (66 mg, 2.8 mmol) and the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was acidified with 2N aq. H2SO4 to pH=7-8, and then extracted with EtOAc (20 mL×3). The combined organic layers were washed with brine, dried (MgSO4), and concentrated to afford the title compound. 1H NMR (D2O, 400 MHz): 8.10 (s, 1H), 7.98 (s, 1H), 7.72 (s, 1H), 7.51 (s, 1H), 7.40 (d, J=8.0 Hz, 1H), 7.32 (d, J=8.4 Hz, 1H), 4.41 (s, 2H), 3.32 (s, 3H), 2.13 (s, 3H).

Provenance & Evidence