HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1845312Generated: November 1, 2026
Diisopropylethylamine → 2'-Cyano-5-(1,2-dihydroxyethyl)-4'-methyl-N-((6-methylpyridin-3-yl)methyl)biphenyl-3-carboxamide
https://huagongshe.com/reaction/1845312
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (6-Methylpyridin-3-yl)methanamine | HCID 12214337 | — |
| Reactant | 2'-Cyano-5-(1,2-dihydroxyethyl)-4'-methylbiphenyl-3-carboxylic acid | HCID 58188326 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2'-Cyano-5-(1,2-dihydroxyethyl)-4'-methyl-N-((6-methylpyridin-3-yl)methyl)biphenyl-3-carboxamide | HCID 58188214 | — |
Reaction Steps
To a solution of 2′-cyano-5-(1,2-dihydroxyethyl)-4′-methylbiphenyl-3-carboxylic acid (30 mg, 0.10 mmol) in N,N-dimethylformamide (1 mL) were added (6-methylpyridin-3-yl)methanamine (35 mg, 0.26 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (100 mg, 0.26 mmol), and N,N-diisopropylethylamine (100 μL, 0.57 mmol). The reaction mixture was stirred for 16 hours at 25° C., and then purified by preparative HPLC to afford the final product as a light color solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08946439B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-8c13fa820fa944babe9f5ebf15647704 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
