HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Furanol, tetrahydro- → Methyl 4'-methyl-5-(tetrahydrofuran-3-yloxy)biphenyl-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Furanol, tetrahydro- | HCID 9960 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | Methyl 5-hydroxy-4'-methyl-[1,1'-biphenyl]-3-carboxylate | HCID 58187967 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4'-methyl-5-(tetrahydrofuran-3-yloxy)biphenyl-3-carboxylate | HCID 58188199 | — |
Reaction Steps
To a stirred solution of methyl 5-hydroxy-4′-methylbiphenyl-3-carboxylate (120 mg, 0.47 mmol), triphenylphosphine (120 mg, 0.47 mmol), 3-hydroxytetrahydrofuran (45 mg, 0.50 mmol) in CH2Cl2 (7 mL) at rt was slowly added a solution of diisopropyl azodicarboxylate (100 mg, 0.50 mmol) in CH2Cl2 (2 mL). The mixture was stirred at rt overnight, and then concentrated in vacuo. The residue was purified by flash chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946439B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-3c061264a35c4d57a36ee264091fd7bb |
| Source note | uspto-grants-2015_02 |