HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1845332Generated: October 31, 2026
Diisopropylethylamine → HCID 58187999, compound
https://huagongshe.com/reaction/1845332
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58188222 | HCID 58188222 | — |
| Reactant | (R)-1-(6-Methylpyridin-3-yl)ethan-1-amine dihydrochloride | HCID 67053782 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58187999 | HCID 58187999 | — |
Reaction Steps
To a solution of 5-((dimethylamino)methyl)-4′-methylbiphenyl-3-carboxylic acid (20 mg, 0.074 mmol) in N,N-dimethylformamide (1 mL) were added (R)-1-(6-methylpyridin-3-yl)ethanamine dihydrochloride (40 mg, 0.19 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (60 mg, 0.16 mmol), and N,N-diisopropylethylamine (200 μL, 1.15 mmol). The reaction mixture was stirred for 16 hours at 25° C., and then purified by preparative HPLC to afford the final product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946439B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-cce707ac888b499eaa1cb3bdac6b7783 |
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| Source note | uspto-grants-2015_02 |
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