Hydrochloric Acid → HCID 58188337, compound

Participants

Reaction Conditions

Reaction Steps

Into a 20 mL reaction vessel were combined methyl 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoate (50 mg, 0.15 mmol), tetrahydrofuran (10 mL) and lithium hydroxide (8.7 mg, 0.36 mmol). The mixture was heated at 50° C. for 3 hours. After cooling, the mixture was treated with 7 M aq. HCl (52 μL, 0.36 mmol), and concentrated to afford the crude compound which was used directly in the next step.

Provenance & Evidence