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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1845367Generated: October 29, 2026

Hydrochloric Acid → HCID 57826814, compound

https://huagongshe.com/reaction/1845367

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86633544HCID 86633544—
SolventDichloromethaneHCID 6344—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 57826814HCID 5782681468.4%

Reaction Steps

To a solution of 1,1-dimethylethyl[(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-(3-pyridinylmethyl)ethyl]carbamate (796.7 mg, 2.1 mmol) in DCM (10 mL) at RT was added 1M HCl in dioxane (10 mL). After 20 h, the solution was concentrated affording the title compound (404 mg, 68%) as the HCl salt: LCMS (ES) m/z 282 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08946278B2
Source datasetuspto-grants-2015_02
ORD IDord-17f3288b8bb44420a40338c664c2a5c2
Source noteuspto-grants-2015_02