Bromine → 134077-72-8

HRID 1845764Notes

Reaction equation

HRID 1845764 reaction equation
C[O:2][CH2:3][C:4]1[S:8][N:7]=[N:6][C:5]=1[C:9]([O:11][CH3:12])=[O:10].BrBr>C(Cl)(Cl)(Cl)Cl>[CH:3]([C:4]1[S:8][N:7]=[N:6][C:5]=1[C:9]([O:11][CH3:12])=[O:10])=[O:2]

Participants

4

Reactant 2

HCID 24408BromineHCID 2825090HCID 2825090, compound

Product 1

HCID 14913987134077-72-8Yield 71.3%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Methyl 5-(methoxymethyl)-1,2,3-thiadiazole-4-carboxylate (4.18 g, 0.022 mol) was dissolved in carbon tetrachloride (60 mL). To the solution was added bromine (4.18 g, 0.026 mol) and the solution was refluxed upon irradiation with long wavelength UV light (100 watts) for 3 h. The volatiles were evaporated in vacuo and the crude material purified by flash chromatography to give the desired product (2.70 g, 71%) as a viscous oil. 1H NMR (400 MHz, CDCl3): δ□ 10.67 (s, 1H), 4.15 (s, 3H). MF=C5H4N2O3S; LCMS calculated for C5H5N2O3S (M+H)+: m/z=173.0.

Workup

  1. temperaturethe solution was refluxed upon irradiation with long wavelength UV light (100 watts) for 3 h
  2. customThe volatiles were evaporated in vacuo
  3. customthe crude material purified by flash chromatography

Sources & evidence

ORD record
ord-5d13f68d1b1f45a5a32898309e525e97
Source dataset
uspto-grants-2015_02
Patent number
US08951536B2

Reaction notes

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