Morpholine → HCID 178420764, compound

HRID 1845780Notes

Reaction equation

HRID 1845780 reaction equation
Cl[CH2:2][C:3]1[NH:7][N:6]=[N:5][N:4]=1.[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>>[NH:7]1[C:3]([CH2:2][N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][N:5]=[N:6]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178478452HCID 178478452, compound

Product 1

HCID 178420764HCID 178420764, compoundYield 82%

Procedure

A solution of 5-(chloromethyl)-1H-tetrazole (260 mg, 2.2 mmol) in morpholine (1.5 mL, 17.2 mmol) was stirred at 25° C. for 20 minutes. The crude reaction mixture was purified by preparative LCMS using pH 2 buffer to yield the desired product (300 mg, 82%). MF=C6H11N5O; LCMS calculated for C6H12N5O (M+H)+: m/z=170.1.

Workup

  1. customThe crude reaction mixture
  2. customwas purified by preparative LCMS

Sources & evidence

ORD record
ord-8a4250f3675d4d968aab1590ef01e58d
Source dataset
uspto-grants-2015_02
Patent number
US08951536B2

Reaction notes

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