反应详情

温度

0 °C

N-(3-Chloro-4-fluorophenyl)-4-(3-hydroxypropyl)-1,2,5-oxadiazole-3-carboxamide (60 mg, 0.20 mmol) was dissolved in anhydrous DCM (2 mL), followed by addition of TEA (57 μL, 0.41 mmol). The reaction was stirred and cooled to 0° C., and methanesulfonyl chloride (29 μL, 0.37 mmol) was added drop-wise. The reaction was quenched with water and diluted with DCM. The organic layer was separated, dried over Na2SO4, filtered, concentrated and purified by silica gel chromatography (25%-75% EtOAc/hexane) to give the desired product (60 mg, 80%). LCMS for C13H14ClFN3O5S (M+H)+: m/z=378.

1. customThe reaction was quenched with water
2. additiondiluted with DCM
3. customThe organic layer was separated
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. custompurified by silica gel chromatography (25%-75% EtOAc/hexane)