Phosphine oxide, (chloromethyl)dimethyl- → HCID 60168432, compound

HRID 1845834Notes

Reaction equation

HRID 1845834 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([O:12][C:13]1[C:14]([NH2:24])=[N:15][CH:16]=[C:17]([C:19]2[CH:20]=[N:21][NH:22][CH:23]=2)[CH:18]=1)[CH3:11].Cl[CH2:26][P:27](=[O:30])([CH3:29])[CH3:28]>>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([O:12][C:13]1[C:14]([NH2:24])=[N:15][CH:16]=[C:17]([C:19]2[CH:23]=[N:22][N:21]([CH2:26][P:27]([CH3:29])([CH3:28])=[O:30])[CH:20]=2)[CH:18]=1)[CH3:11]

Participants

3

Reactant 2

HCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 21110756HCID 21110756, compound

Product 1

HCID 60168432HCID 60168432, compound

Procedure

The title compound was prepared from 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1H-pyrazol-4-yl)-pyridin-2-ylamine and chloromethyl-dimethyl-phosphine oxide following the same procedure as Example 2. ESMS: m/z 457 (M+H)+.

Sources & evidence

ORD record
ord-98924f7c01b449129d69a8ae8ed32289
Source dataset
uspto-grants-2015_02
Patent number
US08951993B2

Reaction notes

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