Phosphine oxide, (chloromethyl)dimethyl- → HCID 60168434, compound

HRID 1845835Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([O:16][CH:17]([C:19]3[C:24]([Cl:25])=[CH:23][CH:22]=[C:21]([F:26])[C:20]=3[Cl:27])[CH3:18])[C:12]([NH2:15])=[N:13][CH:14]=2)=[CH:5][CH:4]=1.Cl[CH2:29][P:30](=[O:33])([CH3:32])[CH3:31]>>[CH3:29][P:30]([CH2:32][N:1]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[C:11]([O:16][CH:17]([C:19]3[C:24]([Cl:25])=[CH:23][CH:22]=[C:21]([F:26])[C:20]=3[Cl:27])[CH3:18])[C:12]([NH2:15])=[N:13][CH:14]=2)=[CH:7][CH:8]=1)[CH2:29][P:30]([CH3:32])([CH3:31])=[O:33])([CH3:31])=[O:33]

Participants

Reactant 2

HCID 74224Phosphine oxide, (chloromethyl)dimethyl-

HCID 68194238HCID 68194238, compound

Product 1

HCID 60168434HCID 60168434, compound

Procedure

the title compound (di-alkylation product) was prepared from 5-[4-(aminomethyl)phenyl]-3-[1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine and chloromethyl-dimethyl-phosphine oxide following the same procedure as Example 2. ESMS: m/z 584 (M+H)+.

Sources & evidence

ORD record: ord-7eb982c1af6441f5a946686a9a1191d3
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08951993B2

Reaction notes

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