5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine → HCID 60168525, compound

HRID 1845839Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:22]1[C:27]([O:28][CH3:29])=[CH:26][C:25](B(O)O)=[C:24]([F:33])[CH:23]=1.[CH3:34][PH:35](=[O:37])[CH3:36]>>[Cl:20][C:13]1[C:14]([F:19])=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:25]2[CH:26]=[C:27]([O:28][CH3:29])[C:22]([P:35]([CH3:36])([CH3:34])=[O:37])=[CH:23][C:24]=2[F:33])[CH:3]=1)[CH3:11]

Participants

Reactant 3

HCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

HCID 68194128HCID 68194128, compound

HCID 178503022methylphosphonoylmethane

Product 1

HCID 60168525HCID 60168525, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromo-2-fluoro-5-methoxyphenylboronic acid, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3. ESMS: m/z 501 (M+H)+.

Sources & evidence

ORD record: ord-a68cfaae36f041e79cca4a3c738d2ac8
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08951993B2

Reaction notes

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