5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine → HCID 68194489, compound

HRID 1845841Notes

Reaction equation

HRID 1845841 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][C:23]=1[O:31][CH3:32].[CH3:33][PH:34](=[O:36])[CH3:35]>>[Cl:20][C:13]1[C:14]([F:19])=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:25]2[CH:26]=[CH:27][C:22]([P:34]([CH3:35])([CH3:33])=[O:36])=[C:23]([O:31][CH3:32])[CH:24]=2)[CH:3]=1)[CH3:11]

Participants

4

Reactant 3

HCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amineHCID 53216279(4-Bromo-3-methoxyphenyl)boronic acidHCID 178503022methylphosphonoylmethane

Product 1

HCID 68194489HCID 68194489, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromo-3-methoxyphenyl boronic acid, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 483 (M+H)+.

Sources & evidence

ORD record
ord-e056998912fb4ad88ff6ebc19b7aef12
Source dataset
uspto-grants-2015_02
Patent number
US08951993B2

Reaction notes

Loading…