5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine → HCID 60168625, compound

HRID 1845847Notes

Reaction equation

HRID 1845847 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:22]1[CH:23]=[CH:24][C:25](B(O)O)=[N:26][CH:27]=1.[CH3:31][PH:32](=[O:34])[CH3:33]>>[Cl:20][C:13]1[C:14]([F:19])=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:25]2[CH:24]=[CH:23][C:22]([P:32]([CH3:33])([CH3:31])=[O:34])=[CH:27][N:26]=2)[CH:3]=1)[CH3:11]

Participants

4

Reactant 3

HCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amineHCID 22832077(5-Bromopyridin-2-yl)boronic acidHCID 178503022methylphosphonoylmethane

Product 1

HCID 60168625HCID 60168625, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 5-bromo-2-pyridinylboronic acid, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 454 (M+H)+.

Sources & evidence

ORD record
ord-de14dd92f9484534aaa8fbed5a7f7801
Source dataset
uspto-grants-2015_02
Patent number
US08951993B2

Reaction notes

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