(4-Bromophenyl)boronic acid → HCID 60168723, compound

HRID 1845851Notes

Reaction equation

HRID 1845851 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[Cl:19])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1.[CH3:30][PH:31](=[O:33])[CH3:32]>>[Cl:19][C:13]1[CH:14]=[CH:15][C:16]([F:18])=[CH:17][C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:21]2[CH:26]=[CH:25][C:24]([P:31]([CH3:32])([CH3:30])=[O:33])=[CH:23][CH:22]=2)[CH:3]=1)[CH3:11]

Participants

4

Reactant 3

HCID 79599(4-Bromophenyl)boronic acidHCID 67463521HCID 67463521, compoundHCID 178503022methylphosphonoylmethane

Product 1

HCID 60168723HCID 60168723, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2-chloro5-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromophenylboronic acid, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 418 (M+H)+.

Sources & evidence

ORD record
ord-032d0b9751794923a3683914170ce54d
Source dataset
uspto-grants-2015_02
Patent number
US08951993B2

Reaction notes

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