反应详情

1-(2-hydrazinopyrimidin-4-yl)ethanol (13a) was dissolved in ethanol (300 mL) and Raney-Ni (35 mL, 50% slurry in water) was added. The flask was flushed with argon, put under a hydrogen atmosphere (balloon) and stirred at room temperature overnight. The mixture was filtered and concentrated under vacuum to give a red oil that was dissolved in methanol and concentrated onto silica before being purified by silica flash chromatography (100% ethyl acetate to 20% methanol in ethyl acetate) to give the title compound (9.0 g) as an orange oil.

1. customThe flask was flushed with argon
2. filtrationThe mixture was filtered
3. concentrationconcentrated under vacuum
4. customto give a red oil that
5. concentrationconcentrated onto silica
6. custombefore being purified by silica flash chromatography (100% ethyl acetate to 20% methanol in ethyl acetate)