Tetrabutylammonium Fluoride → HCID 67256425, compound

Participants

Reaction Steps

To a solution of 4-(2-(tert-butyldimethylsilyloxy)-1-(2-chloro-4-fluorophenoxy)ethyl)pyrimidin-2-amine (20a) (830 mg) in tetrahydrofuran (15 mL) was added tetrabutyl-ammonium fluoride (1 g) and the mixture was stirred at room temperature for 5 days. The mixture was concentrated and purified by column chromatography using 0 to 10% methanol in dichloromethane to give the title compound (348 mg) as a white solid.

Provenance & Evidence