Sodium methanethiolate → HCID 67261027, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-4-(1-(6-fluoro-pyridin-2-yloxy)ethyl)pyrimidin-2-amine (389 mg) (prepared as described for (R)-4-(1-(6-fluoro-pyridin-2-yloxy)ethyl)pyrimidin-2-amine but starting from 1-(2-aminopyrimidin-4-yl)ethanol) in dry dimethylsulfoxide (10 mL) was added sodium methanethiolate (582 mg) the solution was stirred for 5 min and then heated with microwave irradiation at 140° C. for 300 sec. The resulting mixture was quenched into water (300 mL) the resulting solid was filtered and washed with water and dried. The solid was triturated with heptane and further to give the title compound (226 mg) as a pale brown solid, MS (ES): m/z 263 [M+H]+.

Provenance & Evidence