反应详情

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine (24.0 g, 79.9 mmol) was dissolved in acetonitrile (250 mL), and to which was added NBS (14.2 g, 79.9 mmol) under the cooling of ice bath. After 15 min, the solvent in the resultant mixture was evaporated under reduced pressure, and then purified via silica gel column chromatography (petroleum ether:ethyl acetate=3:1) to yield the target product as solid powder of soil colour (23.2 g, 61.1 mmol; yield=76%).

1. temperaturecooling of ice bath
2. customthe solvent in the resultant mixture was evaporated under reduced pressure
3. custompurified via silica gel column chromatography (petroleum ether:ethyl acetate=3:1)