3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-(diphenylmethyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine → 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine

Participants

Reaction Steps

The product of the above mentioned Example 9 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-(diphenylmethyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine (2.2 g, 3.73 mmol) was dissolved in methanol (40 mL), and palladium hydroxide/carbon (220 mg) was added to perform the hydrogenation reaction. TLC test showed that the raw materials were completely reacted. After filtration, the filtrate was concentrated under reduced pressure to yield the target product as white solid powder.

Provenance & Evidence