(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine → (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine

Participants

Reaction Steps

The compound (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (15.2 g, 45.9 mmol) was suspended in ethanol (150 mL), and palladium/carbon was added to perform the hydrogenation reaction. TLC test showed that the raw materials were completely reacted. The reaction liquid was filtered; the filtrate was concentrated under reduced pressure to remove ethanol to yield (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine (12 g, yield: 87%).

Provenance & Evidence