Hydrochloric Acid → HCID 54577789, compound

Participants

Reaction Steps

To a round bottom flask was added tert-butyl 4-{[6-(2-cyanophenyl)-2-oxo-1,3-benzothiazol-3(2H)-yl]methyl}piperidine-1-carboxylate (11-2) (0.242 g, 0.538 mmol), MeOH (2.5 mL), DCM (2.5 mL), and a sat'd solution of HCl in EtOAc (˜4N) (1.346 mL, 5.38 mmol). The reaction mixture was capped and permitted to stir for two hours then concentrated to give 2-[2-oxo-3-(piperidin-4-ylmethyl)-2,3-dihydro-1,3-benzothiazol-6-yl]benzonitrile (11-3) as a tan solid. HRMS (M+H)+: observed=350.1322, calculated=350.1322.

Provenance & Evidence