HCID 58080792, compound → HCID 58080922, compound

HRID 1845950Notes

Reaction equation

HRID 1845950 reaction equation
C(OC([NH:11][C:12]([CH3:27])([CH3:26])[CH2:13][N:14]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:16][CH2:17][OH:18])=O)C1C=CC=CC=1.[H][H]>[C].[Pd].C(O)C>[NH2:11][C:12]([CH3:27])([CH3:26])[CH2:13][N:14]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][CH2:16][CH2:17][OH:18]

Participants

5

Reactant 2

HCID 58080792HCID 58080792, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58080922HCID 58080922, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

0.11 g of palladium-carbon was added to an ethanol (30 mL) solution of 1.1 g of 2-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl-3-hydroxypropylamino)-2-methylpropane, and the mixture was stirred at room temperature for 2 hours in a hydrogen atmosphere. After the completion of reaction, the reaction solution was concentrated to obtain the compound of interest.

Workup

  1. customAfter the completion of reaction
  2. concentrationthe reaction solution was concentrated
  3. customto obtain the compound of interest

Sources & evidence

ORD record
ord-bf4ac42b165f4fd4b59645e3981c45c7
Source dataset
uspto-grants-2015_02
Patent number
US08951997B2

Reaction notes

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