反应详情

0.5 mL of triethylamine and 0.5 g of tert-butoxycarbonylpiperazine were added with stirring at room temperature to a dichloromethane solution (100 mL) of 6-chlorosulfonylisoquinoline (Reference Compound 2) synthesized according to Reference Example 2 from 500 mg of 6-aminoisoquinoline (Reference Compound 1), and reacted for 6 hours. After the completion of reaction, the reaction solution was washed with saturated saline and dried over anhydrous sodium sulfate. After concentration, the obtained crude product was purified by silica gel column chromatography (ethyl acetate:hexane=1:1) to obtain 150 mg of the compound of interest as a white crystal (23%).

1. customsynthesized
2. customreacted for 6 hours
3. customAfter the completion of reaction
4. washthe reaction solution was washed with saturated saline
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationAfter concentration
7. customthe obtained crude product
8. customwas purified by silica gel column chromatography (ethyl acetate:hexane=1:1)