Trifluoroacetic acid → HCID 49847657, compound

Participants

Reaction Steps

1.1 g of (S)-6-(4-tert-butoxycarbonyl-2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline was dissolved in 50 mL of dichloromethane, and 1.8 mL of trifluoroacetic acid was added dropwise thereto at room temperature and then reacted for 6 hours. The reaction solution was neutralized with a saturated aqueous solution of sodium bicarbonate, followed by extraction with dichloromethane (50 mL×2). The extract was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the obtained crude product was purified by silica gel column chromatography (dichloromethane:methanol:28% ammonia water=10:1:0.05) to obtain 0.4 g of the compound of interest as a white crystal (48%).

Provenance & Evidence