m-Chloroperbenzoic acid → HCID 66727336, compound

Participants

Reaction Steps

340 mg of (S)-6-(4-tert-butoxycarbonyl-2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline was dissolved in 20 mL of dichloromethane, and 244 mg of m-chloroperbenzoic acid was added at 0° C. The reaction solution was stirred at room temperature for 16 hours and then concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (ethyl acetate:methanol=8:1) to obtain 320 mg of the compound of interest as a colorless oil (91%).

Provenance & Evidence